A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz Gonzalez, Morri E. Feldman, Eli R. Zunder, David D. Goldenberg, Olusegun Williams, Robbie Loewith, David Stokoe, Andras Balla, Balazs Toth, Tamas Balla, William A. Weiss, Roger L. Williams, and Kevan M. Shokat* Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute Departments of Neurology and Pediatrics, Neurological Surgery and Brain Tumor Research Center Comprehensive Cancer Center University of California, San Francisco, San Francisco, CA 94143, USA MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom University of Geneva, Department of Molecular Biology, CH-1211 Geneva 4, Switzerland Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA Present address: Instituto de Quı́mica-Fı́sica ‘‘Rocasolano’’ (CSIC), Serrano 119, 28006 Madrid, Spain. *Contact: [email protected] DOI 10.1016/j.cell.2006.03.035